Presymptom Health has secured £200,000 in additional grant funding to speed-up its AI-driven infection detection technology.
The Leeds startup says the cash injection will be used to make its rapid tests compatible with a variety of widely available PCR machines, streamlining diagnostics is secondary care.
Presymptom Health was established to exploit IP developed by scientists working at the UK Defence Science & Technologies Laboratory (Dstl), initially researching how to tackle biological threat infection, such as anthrax, plague and Ebola.
Ploughshare – the company that finds new and inspiring uses for government inventions – identified the innovation as having potential societal impact and spun it out from the UK Ministry of Defence in 2019.
Presymptom’s InfectiClear technology can detect infection up to three days earlier than current methods by analysing the body’s RNA-based response rather than searching for the pathogen itself.
Trained and validated on 15 years’ worth of patient data, the AI-driven test ensures that doctors can correctly detect the presence, or lack, of infection, at the earliest possible opportunity – typically in just 40-60 minutes.
It says this approach provides an early, highly sensitive signal for infection or sepsis and avoids the delays and inaccuracies often seen with traditional tests, which can lead to unnecessary or incorrect treatments.
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“Identifying infections quickly and accurately is critical – not just for saving lives, but for ensuring antibiotics are only used when absolutely necessary,” said Dr Iain Miller, CEO.
“Misdiagnosing an infection, or missing it altogether, can have devastating consequences, while unnecessary antibiotic use fuels antimicrobial resistance, one of the biggest global health threats we face.
“The NHS (and most hospitals around the world) relies on a variety of PCR platforms from different manufacturers, which can make rolling out new diagnostic tests a challenge. By ensuring our technology is broadly compatible across multiple platforms, we’re making it easier for hospitals to adopt faster, more accurate infection detection.
“Whether tests are run at the point of care by nurses or in labs by technicians, this flexibility means better diagnoses for all patients. Ultimately, this will improve patient outcomes while also helping the fight against antimicrobial resistance.”
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This new funding will also help ensure that the NHS can make best use of existing PCR machines, many of which have been underutilised since the peak of the COVID-19 pandemic.
The funding includes £100k from the National Institute for Health and Care Research (NIHR) Grant, which will enable Presymptom to make its technology compatible with the PCR platform manufactured by QuantuMDx.
TheQuantuMDx platform can deliver results in 40 minutes and tests will be available at the point of care.
£100k from the Small Business Research Initiative (SBRI) Healthcare Grant – a funding program designed to provide financial support to early-stage healthcare innovations with potential to improve patient care and system efficiency - will help Presymptom Health make its technology compatible with the Mic PCR platform manufactured by Bio Molecular Systems (BMS), which is widely used across the NHS.
Tests run on the BMS platforms can potentially deliver results in under one hour when undertaken in the lab.
As part of the SBRI grant, Presymptom will run a six-month feasibility project alongside Health Innovation Oxford and Thames Valley (HIOTV), to understand barriers to entry and the best approach for the NHS adopting this new technology.
The news follows funding from Innovate UK in 2024 directed to delivering InfectiClear technology on the ThermoFisher Scientific Quantstudio 5 PCR platform – another PCR platform widely used across the NHS.
The company is also planning to raise a Series A funding round over the coming months to help it accelerate its expansion into the US market.
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